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Kenneth Ouriel, MD, MBA

Chief Medical Officer

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expertise areas:

Clinical

Dr. Kenneth Ouriel is widely recognized as one of the country’s leading Vascular Surgeons, publishing more than 300 scientific articles and five textbooks. He is a frequent presenter at national and international conferences and brings over 30 years of experience in medical research.

Dr. Ouriel pursued his undergraduate studies at the University of Rochester (New York). After earning his Bachelor’s Degrees in Biology and Psychology, he studied medicine at the Pritzker School of Medicine at the University of Chicago. He then completed his residency in General Surgery and fellowship in Vascular Surgery at the University of Rochester, where he remained a valued faculty member for over a decade.

In 1998, he became Chief of Vascular Surgery at the Cleveland Clinic, where he was later promoted to the Chief of Surgery in 2003. In 2008, Dr. Ouriel served as Senior Vice President of International Operations at New York-Presbyterian Hospital while earning an MBA (Master of Business Administration) from Columbia University (New York) and the London Business School (United Kingdom).

In 2010, Dr. Ouriel founded Syntactx, a Clinical Research Organization (CRO) that focused on Cardiovascular medical device trials. Syntactx was acquired by NAMSA in December 2020, with Dr. Ouriel assuming the role of Chief Medical Officer.

CORE COMPETENCIES

  • Clinical trial design and execution
  • Minimally invasive treatment of cardiovascular disease, in particular, aortic aneurysms, peripheral arterial occlusive disease, carotid artery disease
  • Pharmacologic treatment of vascular occlusion
  • Treatment of venous thrombotic disorders

RECENT PROJECTS

  • The ARC-ARCH initiative on guidelines and standardization for the diagnosis and treatment of aortic arch disease
  • Investigation of the unanticipated excess mortality observed after drug-coated balloon treatment of lower extremity disease

PUBLICATIONS

  • Ouriel K, Zarins CK: Doppler ankle pressure.  An evaluation of three methods of expression.  Arch Surg 117:1297-1300, 1982.
  • Ouriel K, May AG, Ricotta JJ, DeWeese JA, Green RM: Carotid endarterectomy for nonhemispheric symptoms.  Predictors of success.  J Vasc Surg 1:339-345, 1984.
  • Ouriel K, Fiore WM, Geary JE: Limb threatening ischemia in the medically compromised patient. Amputation or revascularization.  Surgery  104:667-672, 1988.
  • Ouriel K, Geary K, Green RM, Fiore W, Geary JE, DeWeese JA: Factors determining survival after ruptured aortic aneurysm: The hospital, the surgeon, and the patient.  J Vasc Surg 11:493-496, 1990.
  • Ouriel K, Green RM, Donayre CE, Shortell CK, Cimino CD, Donnelly JA, Oxley DJ, Green RM: The hemodynamics of thrombus formation in arteries.  J Vasc Surg 14:757-763, 1991.
  • Ouriel K, Green R, Donayre C, Shortell C, Elliott J, DeWeese J: An evaluation of new methods of expressing aortic aneurysm size: Relationship to rupture. J Vasc Surg 15:12-20, 1992.
  • Ouriel K, Shortell CK, Green RM, DeWeese JA: Intraoperative autotransfusion in aortic surgery.  J Vasc Surg 18:16-22, 1993.
  • Chuter TA, Green RM, Ouriel K, Fiore WM, DeWeese JA: Transfemoral endovascular aortic graft replacement. J Vasc Surg 18:185-197, 1993.
  • Ouriel K, Shortell C, DeWeese JA, Green RM, Francis C, Azodo M, Gutierrez O, Manzione J, Cox C, Marder V: A Comparison of Thrombolytic Therapy with Operative Revascularization in the Initial Treatment of Acute Peripheral Arterial Ischemia. J Vasc Surg 19:1021-1030, 1994.
  • Ouriel K, Moss AJ: Long QT syndrome: an indication for cervicothoracic sympathectomy. Cardiovasc Surg, 3:475-478, 1995.
  • Ouriel K, Veith FJ, Sasahara AA. A Comparison of Recombinant Urokinase with Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs. N Engl J Med 1998;338:1105-11.
  • Ouriel K, Green R, Waldman D, Greenberg R, Shortell C, Illig K. A model for merging vascular surgery and interventional radiology:  Clinical and economical implications.  J Vasc Surg 1998;28:1006-1013.
  • Ouriel K, Kandarpa K, Schuerr D, Hultquist M, Hodkinson G, Wallin B. Prourokinase versus Urokinase for Recanalization of Peripheral Occlusions, Safety and Efficacy:  The PURPOSE Trial.  J Vasc Interv Radiol 1999;10:1083-1091.
  • Ouriel K, Greenberg R, Green R, Massullo J and Goines D. A volumetric index for the quantification of deep venous thrombosis.  J Vasc Surg 1999;30:1060-1066.
  • Ouriel K, Green R, Greenberg R, Clair D. The Anatomy of Deep Venous Thrombosis of the Lower Extremity.  J Vasc Surg 2000;31:895-900.
  • Illig K, Moran S, Serletti J, Ouriel K, Orlando G, Smith A, Shortell C, Green R. Combined Free Tissue Transfer and Infrainguinal Bypass Graft: An Alternative to Major Amputation in Selected Patients. J Vasc Surg 2000;33:17-23.
  • Traul DK, Clair DG, Gray B, O’Hara PJ, Ouriel K. Percutaneous endovascular repair of infrarenal abdominal aortic aneurysms: a feasibility study. J Vasc Surg 2000.
  • Matsumura J, Ryu R, Ouriel K. Identification and implications of transgraft microleaks after endovascular repair of aortic aneurysms.  J Vasc Surg 2001;34:190-197.
  • Ouriel K. Peripheral Arterial Disease.  The Lancet 2001;358:1257-1264.
  • Ouriel K, Greenberg RK, Clair DG. Long-term Results of Aortic Stent Grafts: The Cleveland Clinic Experience.  J Endovasc Ther 2003;SI:I32-33.
  • Ouriel K. Thrombi – beware of red cells bearing gifts.  Nature Biotechnology 2003; 21(8):871-872.
  • Ouriel K, Castaneda F, McNamara T, Swischuk J, Tepe G, Smith J, Clark J, Duda S. Reteplase Monotherapy and Reteplase/Abciximab Combination Therapy in Peripheral Arterial Occlusive Disease: Results from the RELAX Trial.  JVIR 2004;15:229-238.
  • Yadav J, Wholey M, Kuntz R, Fayad P, Katzen B, Mishkel G, Bajwa T, Whitlow P, Strickman N, Jaff M, Popma J, Snead D, Cutlip D, Firth B, Ouriel K. Protected carotid stenting versus endarterectomy in high-risk patients.  The stenting and angioplasty with protection in patients at high-risk for endarterectomy investigators.  N Engl J Med 2004;351(15):1493-1501.
  • Greenberg R, O’Neill S, Walker E, Haddad F, Lyden S, Svensson L, Lytle B, Clair D, Ouriel K. Endovascular repair of thoracic aortic lesions with the Zenith TX1 and TX2 thoracic grafts: Intermediate-term results.  J Vasc Surg 2005;41:589-596.
  • Sheehan M, Ouriel K, Greenberg R, McCann R, Murphy M, Fillinger M, Wyers M, Carpenter J, Fairman R, Makaroun M. Are type II endoleaks after endovascular aneurysm repair endograft dependent?  J Vasc Surg 2006; 43:657-61.
  • Bates ER, Babb JD, Casey DE Jr, Cates CU, Duckwiler GR, Feldman TE, Gray WA, Ouriel K, Peterson ED, Rosenfield K, Rundback JH, Safian RD, Sloan MA, White CJ. ACCF/SCAI/SVMB/SIR/ASITN 2007 clinical expert consensus document on carotid stenting: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Committee on Carotid Stenting). J Am Coll Cardiol 2007;49:126-70.
  • Greenberg RK, Lu Q, Roselli EE, Svensson LG, Moon MC, Hernandez AV, Dowdall J, Cury M, Francis C, Pfaff K, Clair DG, Ouriel K, Lytle BW. Contemporary analysis of descending thoracic and thoracoabdominal aneurysm repair: a comparison of endovascular and open techniques.  Circulation 2008;118:808-17.
  • Ouriel K. The PIVOTAL study: a randomized comparison of endovascular repair versus surveillance in patients with smaller abdominal aortic aneurysms.  J Vasc Surg 2009;49:266-9.
  • Ouriel K, Fowl RJ, Davies MG, Forbes TL, Gambhir RP, Morales JP, Ricci MA. Reporting standards for adverse events after medical device use in the peripheral vascular system. J Vasc Surg 2013;58:776-86.
  • Schurrmann RC, Ouriel K, Muhs BE, Jordan WD Jr, Ouriel RL, Boersen JT, de Vries JP. Aortic curvature as a predictor of intraoperative type Ia endoleak. J Vasc Surg 2016;63;596-602
  • Ouriel K, Ouriel RL, Lim YJ, Piazza G and Goldhaber SZ. Computed tomography angiography with pulmonary artery thrombus burden and right-to-left ventricular diameter ratio after pulmonary embolism. Vascular. 2017;25:54-62.
  • Ouriel K, Adelman MA, Rosenfield K, et al. Safety of Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Peripheral Artery Disease. JACC Cardiovasc Interv 2019;12:2515-24.Lookstein RA, Haruguchi H, Ouriel K, et al. Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas. N Engl J Med 2020;383:733-42.